Fragment-based Drug Discovery Market - Worldwide Industry Volume and Region Analysis - 2023

38.4% of the global fragment-based drug discovery market was collectively held by its top three players in 2014. Astex Pharmaceuticals, Charles River Laboratories International, Inc., and Sygnature Discovery were the key contributors to the market revenue at the time and are expected to retain their lead in the near future. A new research report released by Transparency Market Research states that with 52.3% of the global fragment-based drug discovery market occupied by regional players, this highly fragmented market is dominated by local market companies that offer cheaper services. 

The significantly large presence of regional companies is leaving the market in an unorganized state which makes it difficult for prominent players to expand their horizons. The TMR report also states that the threat of new entrants to the market is expected to remain moderate in the coming years, due to a high setup cost and the need for skilled professionals for the programs. Additionally, the market is governed by extremely strict regulations created by bodies such as the FDA and the EMA, further reducing the scope of new entrants into the market.

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FBDD Shows Greater Promise Through Implementation of Novel Technologies

“The scope of fragment-based drug discovery programs has already been quite high in several end-user segments such as biopharmaceuticals,” states a TMR analyst. “There has, however, been the slight hindrance of cost and time being high for several companies. This is changing fast through the implementation of techniques such as combinational chemistry and high-throughput screening. These techniques are not only reducing the time taken for drug discovery, but also cutting down overall costs by a significant amount.”

The potential of fragment-based drugs is already visible through the approval of Vemurafenib, a melanoma drug and the first fragment-based drug ever to be approved. Companies are therefore quickly beginning to realize the potential of fragment-based drug discovery techniques and consequently, the use of modern screening processes that reduce time even further.

Instances of Low Drug Potency Hamper FBDD Growth

While the utility of fragment-based drug discovery is well-established, there are still cases observed where the use of fragment-based drug discovery techniques can only help develop low-potency drugs. This significantly reduces the values of the drug as well as the technique and therefore deters several companies from implementing FBDD techniques.

Owing to the strict regulatory functions surrounding drug development across the world, the potency of drugs have always been a high concern in terms of clinical considerations. Higher potency is always preferred and therefore, fragment hits that result in a potency lower than a minimum level are considered unfruitful.

North America Expected to Continue Leading FBDD Demand

The global market for fragment-based drug discovery is expected to expand at a very optimistic CAGR of 14.4% within a forecast period from 2015 to 2023, in terms of revenue. This revenue is expected to reach US$435.6 mn by the end of 2016 and US$1.15 bn by the end of 2023.

Biopharmaceutical companies have been the largest end users for fragment-based drug discovery programs. By the end of 2023, the revenue earned from them is expected to reach US$565.2 mn. Leading industry practices have allowed North America to retain the top demand for fragment-based drug discovery programs so far. The region is expected to remain dominant till 2023, by when it is expected to reach US$525.2 mn.

The service component of fragment screening has been the most popular so far and is expected to remain the leading segment till 2023. By the end of 2023, fragment screening revenue is expected to reach US$742.3 mn.

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Transparency Market Research (TMR) is a market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. We have an experienced team of Analysts, Researchers, and Consultants, who us e proprietary data sources and various tools and techniques to gather, and analyze information. Our business offerings represent the latest and the most reliable information indispensable for businesses to sustain a competitive edge.

Global Fragment-based Drug Discovery Market Analysis, Trends and Forecast by 2015 - 2023

Fragment-based Drug Discovery Market: Snapshot

The introduction of new techniques into the existing fragment-based drug discovery practices have created significant reductions in time and cost, driving the demand for such practices. Combinational chemistry and high-throughput screening are some of the more recently introduced practices that have helped make fragment-based drug discovery programs a lot faster and cheaper than before. 

Additionally, as the usage of fragment-based drug discovery grows in the field of discovering weaker inhibitors, biophysical techniques become extremely useful. These techniques can be used to measure binding within fragment compounds that possess low affinity for binding.

The demand for fragment-based drug discovery, however, is expected to be greatly hindered by the lowered potency of fragment screening, the most popular component, in certain compounds. The drugs generated have a lower than required potency, thus deterring several end users from approaching this technique.

The collective impact of all such drivers and restraints can be seen on the global fragment-based drug discovery market, which is expected to expand at a CAGR of 14.4% from 2015 to 2023 by revenue. By the end of 2016, this revenue is expected to reach US$435.6 mn and US$1.15 bn by the end of 2023.

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North America Expected to Continue Leading Demand for Fragment-based Drug Discovery Programs

By the end of 2023, the market value of fragment-based drug discovery techniques in North America is expected to be 45.4% of the global market. While this is a drop in market value from its 2014 statistic, North America will still enjoy being a leading geographical segment for advancements in fragment-based drug discovery techniques.

The key factors responsible for the leading role of North America in fragment-based drug discovery programs is the high rate of research and development efforts undertaken by prominent market players in the region. The U.S. and Canada are both countries with advanced healthcare systems and infrastructures, and are often the base of advanced technological implementations, making North America the hub for the latest developments in fragment-based drug discovery.

This region is also ramping up its speed in development of fragment-based drug discovery techniques by employing outsourcing facilities from Asia Pacific. The demand for fragment-based drug discovery in Asia Pacific, on the other hand, is a lot higher than any other major region, owing to the rapid improvements in healthcare infrastructure and focus on better quality management in countries such as Japan and China.

Biopharmaceutical Companies Top the List of Fragment-based Drug Discovery Demand

Fragment-based drug discovery techniques have grown significantly in popularity in the recent years and have found a great scope of use in the biopharmaceuticals. This includes large companies, academic bodies, and CROs. These techniques have helped massively in creating chemical series that possess lead-like properties as they have improved the success rate of creation significantly over the conventional screening methods. Fragment-based drug discovery techniques have also been extremely useful in marking out chemical motifs from multiple targets.

It is a combination of all these factors that are expected to drive the use of fragment-based drug discovery in biopharmaceutical facilities to a revenue generation of US$565.2 mn by the end of 2023. The key providers of fragment-based drug discovery programs include Astex Pharmaceuticals, Charles River Laboratories International, Inc., Sygnature Discovery, Evotec A.G., and Beactica AB.

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About Us    

Transparency Market Research (TMR) is a market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. We have an experienced team of Analysts, Researchers, and Consultants, who us e proprietary data sources and various tools and techniques to gather, and analyze information. Our business offerings represent the latest and the most reliable information indispensable for businesses to sustain a competitive edge.